The immunohistochemical investigation of chymase-, tryptase- and ghrelin-positive cells on the lung of rat after an application of Sambucus nigra

Sambucus nigra (S.nigra) is used in the treatment of many diseases and disorders thanks to its antioxidant, anticarcinogenic, immunostimulating, antiallergic, antiviral, antibacterial properties. Ghrelin has anti-inflammatory effect on oxidative damage various organs cell types. The aim this study was immunohistochemically examine chymase, tryptase, ghrelin rat lung after S. administration. A total 16 male rats were study. assigned two groups, control nigra. 1st group (n=8): No application made. 2nd extract administered at 15 mg/kg by oral gavage for 14 days. Tryptase, ghrelin-positive cells found tissue a spindle-shaped, round, or oval shape. When groups evaluated within themselves, significant increase number positive observed treated group. This showed that nigra, which an immunomodulatory antioxidant effect, increases expression chymase-, tryptase- lungs. Additionally, based our findings, it can be said mast produce, store release ghrelin.